ASPIRIN — NOVASPIRIN 123 



easily absorbed. Furthermore, it is a non-irritating intestinal anti- 

 septic. On account of its insolubility in the gastric juice salol is often 

 used as a coating for pills which are intended for action upon the 

 intestines. Poisoning takes place after large doses from the freed 

 phenol. 



Circulatory System. It is not so depressing as salicylic acid. 



Absorption and Elimination. This is similar to that of the 

 salic;}lates in general. Salol renders the urine aseptic and for this 

 reason is used in inflammation of the bladder. It also renders the 

 urine acid and causes the. sediment to disappear. 



Therapeutics. 



1. Fermentations of the digestive tract. 



2. As an intestinal antiseptic. Salol is very serviceable in all 

 those cases needing an intestinal antiseptic, such as intestinal catarrh, 

 distemper of dogs, etc. It is too expensive for large animals. 



3. Rheumatism. Salol may be useful in this disease, although its 

 action is less prompt than the salicylate of soda. 



; . 4. Antipyretic. It is inferior to the coal tar antipyretics but 

 may be used for this action. 



"Other members of the salicylate gi-oup. 



ASPIRIN — ACETYL SALICYLIC ACID 



This differs from salol only in having an acetyl instead of a 

 phenol radicle. It occurs as a vphite crystalline powder, soluble in 

 100 parts of water and 5 parts of alcohol. As in the case of salol it 

 passes through the stomach unchanged, but undergoes dissociation 

 in the intestines, liberating salicylic acid, but some may be absorbed 

 unchanged and exhibit a more pronounced salicylate action than salol. 

 It is used as an antirheumatic, intestinal antiseptic and analgesic in 

 functional pains, headache, etc., in human medicine. 



Novaspirin is the methyl-citric-ester of salicylic acid. It occurs 

 as a white, odorless powder, of acidulous taste, is almost insoluble in 

 water, freely soluble in alcohol. It contains 62 per cent, of salicylic 

 acid and is intended as a substitute for the salicylates in various 



conditions. 



Diaspirin is the succinic acid ester of salicylic acid, occurring 

 as an odorless, almost tasteless, crystalline powder very sparingly 

 soluble in the ordinary fluids but slowly decomposing in alkaline 

 liquids. Used largely as aspirin but is more strongly diaphoretic. 



Salicin is a glucoside obtained from the bark of the willow and 

 poplar. It is bitter but not nauseating. In the stomach or duo- 

 denum it splits into salicyl alcohol and other close allies of salicylic 

 acid. Its action is quite similar to those of the other salicylates but 



