124. ANTIPYRETICS 



milder. Its uses are confined to the milder rheumatic manifesta- 

 tions, or in conditions of the stomach where the ordinary salicylates 

 cannot be administered. 



Saliphen (salicyl-paraphenetidin) occurs as colorless crystals 

 readily soluble in alcohol and almost insoluble in water, is a mild 

 analgesic and antipyretic. 



Salopheu (acet-amido-salol.) It is a white, odorless, tasteless 

 powder, soluble in alcohol, insoluble in water, contains 51 per cent, 

 of salicylic acid and is decomposed by alkalies. It is an anodyne, 

 antiseptic, antipyretic and antirheumatic. Used externally in 10 per 

 cent, ointment. 



Atophan is chemically phenyl-quinolin-carboxylic acid. Ato- 

 phan stimulates the kidneys, increases the amount of urine and 

 furthermore has a specific or selective action by which it increases 

 the amount of uric acid excreted to a greater ratio than the increase 

 in the amount of urine. It is claimed to have a more prompt and 

 stronger effect on the excretion of uric acid than sodium salicylate. 

 It is useful in gout of man, in which it acts more promptly than 

 colchicum. 



Doses. Dog. grs. vijss — xv; 0.5 — 1.0, three or four times 

 daily. 



Novatophan is a similar product but is almost tasteless. If either 

 of these agents is used to any extent in veterinary medicine. 



Malakin is salicyl-para-phenetidin. It is a condensation product 

 of salicylic aldehyde in para-phenetidin ; occurs as fine yellow needles, 

 insoluble in water, slightly soluble in alcohol, but freely soluble in 

 solutions of alkali carbonates. It is an antipyretic, antineuralgic and 

 tsenifuge. Dose. Dog. 15 grains, several times daily. 



Mesotan is methyl-oxymethyl-ester of salicylic acid which occurs 

 as a clear yellow fluid, of aromatic odor, miscible with alcohol, ether, 

 chloroform and fatty oils. It possesses the qualities of a volatile 

 oil and is for external use. It is more irritant than methyl salicy- 

 late, so is diluted with an equal amount of olive oil. 



Spirosal is monoglycol salicylate. It occurs as a nearly colorless, 

 odorless, oily fluid, soluble in" alcohol, ether, and chloroform and 

 miscible with fats. It is used as the preceding drug, either in 

 alcoholic or oily solution or as an ointment (50 per cent.). 



Phenocol is most often used as the hydrochloride (amido-acet- 

 para-phenetidin). It occurs as a white, crystalline powder, of bitter 

 sweetish taste, soluble in water and alcohol. Used as an antipyretic 

 and antimalarial. 



Saloquinine is salicyl-quinine, occurs as a whitish, tasteless 

 powder insoluble in water, soluble in acidulated water, chloroform 

 and hot alcohol, sparingly soluble in cold alcohol and ether. It is an 

 analgesic, antiperiodic, and antipyretic, analogous to quinine. 



