228 SPECIFICS FOR THE ALIMENTARY TRACT 



According to Frohner, cats require 10-25 times as much as dogs. 



2. Licking disease. Cattle and Sheep, gr. jss — iij ; 0.1 — 0.2. 



Young Cattle, gr. % — ^jss; 0.05— -0.1. Calves, gr. % — 

 %; 0.02—0.05. 



3. Expectorant. Horses and Cattle, grs. Vs — % ; 0.02 — 0.05. 



Dogs, grs. yeo— y20 ; 0.001—0.003. 



Externally and locally there is no action. 



Digestive System. Apomorphine is the most powerful and cer- 

 tain emetic we possess. Vomition begins in from five to twenty 

 minutes after ingestion, depending on the size of the dose and 

 method of administration, and is repeated at intervals of about 

 fifteen minutes for three or four times. The emesis is preceded and 

 attended by but slight nausea and moderate depression. Apomor- 

 phine is a typical direct or systemic emetic, its entire effect being 

 exerted upon the vomiting center in the medulla. 



Nervous System. Full doses stimulate the brain and may even 

 cause delirium. This is followed by depression and paralysis. If 

 it is administered in very large doses and especially to those animals 

 which do not vomit, it shows its irritant effect upon other parts of the 

 central nervous system. The animals show restlessness, circus move- 

 ments, excitement, fear, and quickened respirations. Convulsions 

 finally set in and death takes place through paralysis of the respira- 

 tory center. 



Circulatory System. Small doses have no effect. During 

 emesis the heart beats faster and stronger and arterial pressure is 

 raised, due to stimulation of the accelerator nerves of the vasomotor 

 system. Large doses paralyze the circulatory apparatus. 



Respiratory System. Small doses do not affect the respirations 

 but increase and fluidify the secretions from the respiratory tract 

 probably by a nauseant action (expectorant). 



Toxicology. Symptoms are violent vomiting, delirium, convul- 

 sions, and marked cardiac and respiratory depression. The treat- 

 ment is similar to that for morphine poisoning. 



Therapeutics. 



1. Emetic for dogs and cats administered hypodermically. 



2. As an expectorant for the sticky mucous discharges in bron- 

 chitis and catarrhal pneumonia. It should be given per os in small 

 doses every two or three hours. 



3. As a specific for licking disease of cattle and wool pulling or 

 eating of sheep, administered subcutaneously. 



51 Apomorphinse Hydrochloridi gr. viij 



Aquae Destillatse q. s ad. 3 j 



M. Ft. Sol. 



Sig. 5 mils (1% 3) once daily for a cow with licking disease. 



Frohner. 



