GRANATUM — POMEGRANATE 273 



Sig. Give at one dose. Follow with a purgative. Repeat treatment 

 in 48 hours if necessary. 



No. 2. Follicular Mange, Dog. 



^ Oleoresinse Aspidii 50. 



Creolini 50. 



Balsami Peruviani 75. 



Alcoholis 500. 



M. Ft. Sol. 



Sig. Apply once daily to affected parts or one-third of the body. 



aRANATUM 



Synonyms. Pomegranate, Granatum Cortex, Pomegranate Bark. 



Parts Used. The bark of the stem and root of Punica Grana- 

 tum, cultivated in subtropical countries. 



Constituents. Pomegranate contains two active liquid alkaloids, 

 Pelletierine or Punicine and Isopelletierine. Besides these there 

 are also two less active alkaloids and a large amount of tannic acid 

 (punico-tannic acid). Pelletierine tannate U. S. P. is a mixture 

 in varying proportions of the tannates of four alkaloids (punicine, 

 isopunicine, methyl-punicine and pseudo-punicine), obtained from 

 pomegranate. It should be kept in small well-stoppered, dark am- 

 ber-colored vials. 



Doses. 



Granatum. D. 3 ss — ij ; 2. — 4. 

 Fluidextractum Granati 3 sa — ij ; 2. — 4. 

 Pelletierinse Tannas. I>. grs. ij — iv; 0.13 — 0.26. 



Local Action. Externally and locally it is astringent on ac- 

 count of the large amount of (punico) tannic acid present but is 

 never used for this action. 



Internally. Small or medicinal doses show no appreciable ef- 

 fect upon the animal except some slight nausea, in animals which 

 vomit, and the passage of the worm. Large doses of the crude 

 drug, especially, are followed by gastro-intestinal irritation, shown 

 by abdominal pain, nausea, vomiting and purging. This action is 

 largely due to the tannic acid contained in the crude drug and conse- 

 quently the administration of the alkaloid is not attended by so 

 much irritation. 



There are also exhibited after administration of large doses, 

 certain nervous disturbances, consisting of increased reflex excit- 

 ability, dullness, loss of coordination and weakness of the limbs. 

 Pelletierine and isopelletierine have a specific action upon tape 

 worms. Schroeder found that a 1 — 10,000 solution would kill them 

 in 10 minutes, while even stronger solutions had but little if any 

 effect upon other intestinal parasites. 



