378 HALOIDS OR HALOGENS 



IODOFORM SUBSTITUTES 



On account of the strong, disagreeable, persistent odor whicli can- 

 not be overcome by the strongest perfumes, many investigations have 

 been made to obtain iodoform substitutes. These have led to several 

 products which have a less disagreeable odor than iodoform. The fol- 

 lovping are the most important : 



* lodoformin is a combination of iodoform with hexamethylena- 

 mine. * lodoformal is a combination of iodof ormin with ethyl io- 

 dide, while * Iodof ormogen is a combination of iodoform with a co- 

 agulated proteid. 



These three preparations have a faint iodoform-like odor. lodo- 

 formin is whitish in color, the others, yellow. The first two liberate 

 iodoform in the presence of water. lodoformin contains 75 per cent, 

 of iodoform and iodoformogen, 10 per cent. The high price and un- 

 certainty of action have limited the use of these preparations. 



*IODOLUM — lODOL 



TETRA-IODO-PYRRHOL 



This is prepared by the action of iodine upon pyrrhol, a prin- 

 ciple obtained from bone oil. It contains a little less than 90 per 

 cent, of iodine, occurs as a grayish brown crystalline powder, devoid 

 of odor and taste. It is almost insoluble in water but is soluble in 

 alcohol, ether and oils. It has the advantage over iodoform of being 

 odorless. 



THYMOLIS lODIDUM — THYMOL IODIDE 



Synonym. Aristol 



Aristol is a proprietary drug introduced to take the place of 

 iodoform. It was and still is very expensive but nevertheless gained 

 so much favor among surgeons that, in the 8th revision of the U. S. P., 

 it was introduced as thymol iodide, which it is chemically. It con- 

 tains about 45 per cent, of iodine, is a light brown or brownish red 

 bulky powder, with a very slight aromatic odor, insoluble in water, 

 slightly soluble in alcohol, biit soluble in ether, chloroform, collodion 

 and oils. It is decomposed by light, heat, acids, alkalies, alcohol and 

 mercuric chloride. 



Uses. Entirely external as a substitute for iodoform, over which 

 it has the advantage of being odorless, but on the other hand it is 

 unstable, and more costly. 



*Europhen. (Di-Isobutyl-Cresol-Iodide). This is a cresol 

 iodide made by precipitating an alkaline solution of isobutyl-ortho- 

 cresol with a solution of iodine in potassium iodide. It contains 25 



* Unofficial. 



