SALVARSAN — NEO-SALVARSAN 



The action and uses are very similar to those of the other ar- 

 senic preparations. It is claimed to be less toxic than arsenic, as 

 are the preceding drugs, but the diminished toxicity is due to the 

 facts that they contain less arsenic, the arsenic is slowly eliminated, 

 and they are not so easily dissociable. Whatever benefit they pos- 

 sess is believed to be due to the slow liberation of arsenic. 



Sodium cacodylate has been recommended for numerous condi^ 

 tions in human practice, such as psoriasis, syphilis, pseudo-leukemia, 

 etc. More recently it has been recommended in veterinary medi- 

 cine for distemper of dogs, and for influenza, contagious pleuro- 

 pneumonia and other infectious fevers of horses. 



Administration. Sodium cacodylate may be given in solution, 

 though almost any method of administration may be used. It is 

 usually given subcutaneously or intratracheally in horses and hypo- 

 dermically in dogs. It may be purchased in ampules ready for ad- 

 ministration to small animals, or may be made into solution. It is 

 usually given about every other day. The following formula will 

 serve as a working basis for preparing solutions of the drug, suitable 

 for hypodermic or intratracheal medication: 



IJ Sodii Cacodylatis gr. xc 



Phenolis in, j 



Aqua Dest. Steril q. s ad. 5 ij 



M.. Ft. Solutio. Boil and filter through a sterile filter. 



Each mil (15 minims) contains approximately 1% grains of the 

 drug. 



* Salvarsan. Ehrlich's 606 — Arsenphenol- Amine-Hydrochlo- 

 ride. This is a bright yellow powder of strongly acid reaction and 

 soluble slowly in 10 parts of water. It may be used subcutaneously 

 or intramuscularly but is recommended especially for intravenous 

 administration. It must be made into a fresh neutral or slightly 

 alkaline solution before administration. It is very oxidizable so is 

 kept " in vacuo " or in ampules filled with an indifferent gas. To 

 prepare it for intravenous use, dissolve it in the proportion of 10 

 grains in 300 mils of physiological salt solution, to which 23 drops 

 of a 15 per cent, solution of caustic soda have been added. 



* Neo-Salvarsan. This is salvarsan so treated that it is soluble 

 in water and neutral in reaction, so that it does not require the addi- 

 tion of an alkali. It, therefore, requires less attention in preparing 



Doses. H. and C. 3xlv— Ixxv; 3.-5. Dog, gr. v— x; 0.3 

 —0.6. 



The two above preparations were brought into prominence for 

 tie treatment of syphilis in man, but have been used by a number 

 * Unofficial. 



