CHOREA. 241 
Fowler’s solution, one-half an ounce; water, one ounce and one-half. 
Puppies can safely bear larger doses of this drug than mature dogs; and 
when over eight months of age for those of breeds of medium size, the com- 
mencing dose may be sixteen drops of the foregoing mixture; for the largest 
breeds, twenty-four drops; for fox terriers and the like, eight drops; and for 
toys, four drops. 
This should be given three times daily, in the food; and the dose be in- 
creased one-fourth after every third day. 
That is, puppies taking at first sixteen drops will, on the fourth day, take 
twenty drops, on the seventh day twenty-four drops, and so on. While for toys 
an increase of one-fourth will be one drop in every instance. 
The mixture having been given thirteen days, and increased four times, it 
should be stopped for three days. Then the administration should be resumed, 
the commencing dose being the same as that being taken when the stop was 
made ; which would be thirty-two drops were the patient of medium size. 
The increase should again go on as before, and continue until four more 
increases have been made. 
A pup of medium size will finally be taking forty-eight drops. 
After this fourth increase, which is the eighth from the beginning, the largest 
dose having been administered for three days, there should be a second stop of 
three days, during which the mixture must be withheld. 
That period of rest will be over on about the thirtieth day of treatment; and 
then the use of the medicine should be resumed, the commencing dose to be the 
same as that which was being given when the stop occurred. 
Thereafter there must not be any further increase. Instead, there must be a 
decrease; and it should be in precisely the same ratio and manner as the in- 
crease. That is, the maximum dose should be given for three days, and then a 
decrease of one-fourth made, and so on. After four decreases there should be a 
halt of three days; and then should follow four more decreases; when the dose 
reached will be the same as at first ; or sixteen drops for pup of medium size. 
Following the eighth decrease, for certainly one more month, even if the 
twitching has stopped, the medicine should be given three times daily, the com- 
mencing and smallest quantity being the dose. 
The twitching is not likely to cease before the largest dose is reached, if it 
does then, but even did the result of treatment prove so eminently satisfactory 
at any stage, the mixture should be persisted in as advised lest relapse occur. 
A return, however, should be made to the commencing dose. That is, in event 
the twitching ceases, further increase should stop at once, and thereafter the 
medicine be given for a month, the dose being the smallest, with which treat- 
ment commenced. 
While puppies will safely bear large doses of arsenic, there are of course 
limits of toleration, and it is assumed that these are reached under this treatment 
