378 FEVERS, AND THEIR TREATMENT. 
difficult of cure ; and it quickly disappeared when no other remedies were 
employed than mild aperients and diaphoretics. A sheep was inoculated 
from one of these dogs. There was a slight eruption of pustules formed on 
the place of inoculation, but nowhere else ; nor was there the least fever. 
“ At another time, also at the school at Lyons, a sheep died of the regular 
sheep-pox. A part of the skin was fastened, during four and twenty hours, 
ona healthy sheep, and the other part of it on a dog, both of them being in 
apparent.good health. No effect was produced on the dog, but the sheep. died 
of confluent sheep-pox. 
“The essential symptoms of small-pox in dogs succeed each other in the 
following order :—The skin of the belly, the groin, and the inside of the fore- 
arm becomes of a redder colour than in its natural state, and sprinkled with 
small red spots irregularly rounded. They are sometimes isolated, sometimes 
clustered together. The near approach of this eruption is announced by an 
increase of fever. 
“On the second day the spots are larger, and the integument is slightly 
tumefied at the centre of each. 
“On the third day the spots are generally enlarged, and the skin is still 
more prominent at the centre. . 
“On the fourth day the summit of the tumour is yet more prominent, To: 
wards the end of that day the redness of the centre begins to assume a some- 
what grey colour. On the following days the pustules take on their peculiar 
characteristic appearance, and cannot be confounded with any other eruption. 
On the summit is a white circular point, corresponding with a certain quantity 
of nearly transparent fluid which it contains, and covered by a thin and trans- 
parent pellicle, This fluid becomes less and less transparent, until it acquires 
the colour and consistence of pus. The pustule, during its serous state, is of 
a rounded form. It is flattened when the fluid acquires a purulent character, 
and even slightly depressed towards the close of the period of suppuration and 
when that of desiccation is about to commence, which ordinarily happens 
towards the ninth or tenth day of the eruption. The desiccation and the 
desquamation occupy an exceedingly variable length of time; and so, indeed, 
do all the different periods of the disease. What is the least inconstant is the 
duration of the serous eruption, which is about four days, if it has been dis- 
tinctly produced and guarded trom all friction. If the general character of 
the pustules is considered, it will be observed that, while some of them are in 
a state of serous secretion, others will only have begun to appear. 
“The eruption terminates when desiccation commences in the first pustules 
and if some red spots show themselves at that period of the malady, they 
disappear without being followed by the development of pustules. They are 
a species of abortive pustules. After the desiccation the skin remains covered 
by brown spots, which by degrees die away. There remains no trace of the 
disease, except a few superficial cicatrices on which the hair does not grow. 
“The causes which produce the greatest variation in the periods of the 
eruption are, the age of the dog, and the temperature of the situation and of 
the season. The eruption runs through its different stages with much more 
rapidity in dogs [rom one to five months old than in those of greater age.” I 
have never seen it in dogs more than eighteen months old. An elevated 
temperature singularly favours the eruption, and also renders it confluent and 
of a serous character. A cold atmosphere is unfavourable to the eruption, or 
even prevents it altogether. Death is almost constantly the result of the 
exposure of dogs having small-pox .to any considerable degree of cold. A 
