34 ANTISEPTIC TREATMENT OF WOUNDS. 
and BRUNS met with good success in their experiments, 
so that especially its antituberculous action is not to be 
doubted. However, iodoform has but a certain limited 
value in surgery and on this account, extravagant use of it is 
discouraged. If we do not consider these clearly theoretical 
and experimental results, practice has shown that we possess 
a very valuable remedy in iodoform, as it possesses excellent 
qualities in certain conditions. 
The action of iodoform depends upon the different modes of 
application as follows: 
First—As powder it does not dissolve in wound exudates, 
but absorbs the latter, and thus excellently dries the wound 
surfaces, so that but little discharge appears; besides, it di- 
rectly restricts the discharges of the wound. 
Second—lIt certainly promotes granulation, because I have 
often observed that peripheral pieces of ligated vascular stumps, 
which otherwise regularly undergo necrosis, granulate pro- 
fusely, by being treated with iodoform. Possibly an explana- 
tion for this is the known close relation of Iodine with the cell 
nuclei. ; 
Third—It acts anaesthetically. 
Fourth—By coming in contact with living animal cells the 
pure iodine gets permanently separated from the iodoform, 
and this pure iodine acts antiseptically. 
Fiith—It certainly has antituberculous actions (BURNS). 
In human surgery it has been observed that iodoform, be- 
sides the valuable qualities just mentioned has many injurious 
ones inasmuch as in a human being iodoform poisoning as 
well as iodoform eczemas sometimes appear after the use of 
the remedy. 
In veterinary practice thus far, iodoform intoxications after 
external applications have been known in dogs only 
(GOOSENS, ALBRECHT, FROHNER). I had no op- 
portunity thus far to notice this probably because I did not use 
excessive doses, which ALBRECHT and GOOSENS give as 
their cause. Experimentally, POLJAKOW ascertained the 
toxic doses for warm blooded animals to be as follows: 0.5 
° 
