MATERIA MEDICA AND THERAPEUTICS. 6l 



Toxicology — Externally. — It inflames the skin and may even 

 cause gangrene. Internally will cause gastro-enteritis, diarrhoea 

 and emesis (in those. that can vomit), 15 grs. in horses and cattle 

 cause gastro-enteritis. Large doses, such as 30 grs. in horses 

 and cattle, and y 2 to 1 gr. in dogs and men, produce paresis, con- 

 vulsions, coma and death, usually within 2 or 3 days. Paralysis 

 of the heart may cause sudden death. 



* Moderate to full doses repeated several times daily may 

 within a few days produce fatty degeneration of the albuminoid 

 tissues or hypertrophy of connective tissues and acute cirrhosis. 

 Persons working in' match factories or with phosphorus con- 

 stantly are liable to suffer from necrosis of the lower or upper 

 jaw. Slow phosphorus poisoning will cause cirrhosis of the 

 liver. In poisonous doses it destroys the red blood corpuscles, 

 causing acute haemorrhages from fatty degeneration of the arterial 

 walls, fatty degeneration of the stomach, liver and heart, with 

 deep, jaundiced condition, sometimes within 36 hours. This is 

 followed with delirium, convulsions, coma, and death generally 

 from gradual failure 'of both respiration and circulation. It is 

 excreted by the kidneys and lungs, chiefly as phosphorus and 

 phosphoric acid. 



PREPARATIONS OF PHOSPHORUS. 



ZINCI PHOSPHIDUM— Phosphide of Zinc— Dose for 

 horses, 1 to 3 grs. ; dogs, 1-50 to 1-30 of a gr., or 1-10 gr. for very 

 large dogs. 



This preparation is irritating and must be administered with 

 a demulcent the same as phosphorus. It is used by some instead 

 of phosphorus. It occurs as a gray, friable mass, with metallic 

 luster, and contains 24 per cent phosphorus. 



OLEUM PHOSPHORATUM— Phosphorated Oil— Pre- 

 pared by dissolving phosphorus in ether and almond oil, 1 part 

 of phosphorus to 100 parts of the menstruum. Each 100 drops of 

 phosphorated oil contains 1 grain of phosphorus. 



Dose for horses, 1 to 4 drs. ; sheep and pigs, 10 to 30 m. ; 

 cattle, 2 to 5 drs. ; dogs, 1 to 5 m. 



This is a good form for administering phosphorus for rickets 



in dogs : oi. Phosphoratis, mxvj— 3 ss. 



01. Morrhuse, qs: ad 3 iv. 

 M. Sig. — Teaspoonful 3 or 4 times daily. 



