84 SYNOPSIS OE VETERINARY 



The bisulphate of quinine is soluble in 10 parts of water. 

 Dose same as the sulphate. 



quininae hydrobromas — Hydrobromate of Quinine. — 

 It does not produce the head symptoms or ringing in the 

 ears that sulphate of quinine does. Dose the same as sulphate 

 of quinine. Useful in dog practice. 



cinchoninae sulphas. — Hard, white, lustrous, pris- 

 matic crystals, odorless, very bitter taste, soluble at 59 F. in 

 66 parts water and 10 parts alcohol. Dose about 3 times that 

 of quinine. 



Antagonists and Incompatibles. — Tannic acid, iodine and 

 preparations of iodine, form insoluble compounds with cinchona 

 alkaloids. The alkalies, alkaline carbonates, and alkaline earths 

 precipitate them from solutions. This holds good for all alka- 

 loids. The waste producing agents are also antagonists. 



Synergist. — All those agents which promote constructive 

 metamorphosis, as the bitters, iron, arsenic, and mineral acids. 



Physiological Actions. — Cinchona is an astringent, bitter 

 tonic. In its astringency only, does it differ from the action of its 

 alkaloids, which are tonic, antiseptic, antiperiodic, antipyretic, 

 antiphlogistic, antimiasmatic, stomachic, and antiferment, also 

 diminishes reflex action. 1 gr. to 1 oz. prevents development of 

 micro-organisms ; 2 grs. to 1 oz. prevents putrefaction and de- 

 composition. 



The alkaloids are rapidly diffused and slowly excreted, being 

 found in the urine 15 minutes after administration, and for 3 

 days afterwards. At first they promote appetite, digestion, flow 

 of saliva and gastric juice, but long continued they derange the 

 stomach and bowels. 



Action on the Heart. — Small doses stimulate the heart; 

 large doses (2 drs. to 1 oz.) depress it. 



On the brain.- — The brain is exhilarated by small doses and 

 depressed by large ones. 



On Spinal Cord. — Reflex function of spinal cord is lowered 

 by large doses. 



Spleen. — Large doses reduce the size of the spleen. The 

 temperature in fever is lowered, although it does not affect the 

 temperature of a healthy animal. It checks oxidation and les- 

 sens protoplasmic and amoeboid movement. 



