MATERIA MfcDICA AND THERAPEUTICS. 135 



As much as 36 drachms have thus been given to the horse 

 during 24 hours, without producing" toxic symptoms, as a special 

 tolerance for carbolic acid seems to be acquired in tetanus and 

 besides on account of it coagulating albumen it is likely that only 

 a small quantity is absorbed. 



GUAIACOLUM— GUA1 AC OL. 



Synonym — Methy l-Pyro catechin. 



Source. — It is obtained by fractional distillation from Beech- 

 wood creosote, in which it exists in from 60 to 90 per cent. 



Properties. — Pure guaiacol is a limpid, oily, colorless liquid 

 of a strong aromatic odor. 



It is but feebly soluble in water (1 in 200) but it is freely 

 soluble in alcohol, ether, glycerin and fixed oils. 



Preparations. — There are a number of guaiacol compounds, 

 most important of which is Guaiacol Carbonate, others are the 

 Benzoate, Cinnamate, Di-iodide and Salicylate of Guaiacoi, but 

 in veterinary practice I prefer pure Guaiacol and that made by 

 "Merck" seems to be the purest. 



Physiological Actions. — Local anodyne, antipyretic and an- 

 tiseptic. It lowers the temperature of the body when applfed 

 externally. 



It is eliminated largely by the lungs and bronchial mucous 

 membranes, consequently exerting powerful antiseptic action over 

 these parts. It stimulates the appetite. 



Its antiseptic action is also carried on in the intestines. 



Dose. — Horses, 3j. to ij.; dogs, 2 to 10 minims. 



Therapy. — Guaiacol is remarkably efficient in CEdema Glotti- 

 dis, for which use 3 j. mixed with an ounce of water at the time 

 of administration, repeat in y 2 , 1 or 2 hours according to ne- 

 cessity. A sharp counter irritant applied to the throat may aid. 



The prompt use of the drug in these case^jseemsJxLjquiekry" IA^"' 



dissipate the cedema and render a tracheotonj tube unnecessary. 



In Pneumonia the use of guaiacol greatly simplifies the 

 treatment and causes resolution in 2 or 3 days less than the 

 usual time. 



In this disease give: 



