MATERIA MEDICA AND THERAPEUTICS. 249 



The preventive dose is 10 to 30 C. C. (about 150 to 450 min- 

 ims) which should be repeated 6 days later. 



The curative dose, is 50, C. C. (about 750 minims) injected 

 at one time, with subsequent injections of 20, C. C. (about 5 

 drachms) according to circumstances. 



In the writers opinion, if the product could be cheapened, 

 so that one-half to a pint might be administered subcutaneously 

 or intravenously at one time, Antitoxin would rank much higher 

 than at present as a curative agent in tetanus. 



When a patient shows a start for recovery, the administration 

 of antitoxin will then materially hasten it. 



The writer uses Parke, Davis & Co's Tetanus antitoxin in 

 one ounce doses, as a preventive, usually administering a second 

 dose about the sixth day. 



After a case of tetanus starts to recover give 2 to 4 ounces at 

 one injection and 1/2. the quantity in 2 or 3 days, this materially 

 hastens complete recovery. 



TUBERCULIN. 



This is a glycerin extract of the germs of tuberculosis. It 

 contains no living germs of tuberculosis and therefore does not 

 communicate the disease to a healthy animal, the milk of the cow 

 is unaffected by its use and it does not interfere with gestation, 

 even if the cow is ready to calf. 



It is used in veterinary, practice entirely as a diagnostic 

 agent, i. e., to positively diagnose tuberculosis in cattle when it is 

 in its incipient stages and not far enough advanced to make a 

 diagnosis by physical examination. 



Tuberculin may be obtained in what is termed "Concen- 

 trated Tuberculin" and "Tuberculin Solution." Tuberculin will 

 keep for several months. If it is desirous of keeping it in stock, 

 it should be kept in the concentrated form and solutions made 

 as required. 



The solution of the "concentrated Tuberculin" is made by 

 adding 1 C.C. of it to 9 C.C. of a j^ of 1 per cent carbolic acid 

 solution (5 to 1000). 



The solution will retain its activity for 2 or 3 weeks if the 

 vial is unopened and kept in a cool, dark place. 



