MATERIA MEDICA AND THERAPEUTICS. 25 1 



previous day should be regarded as an indication of tuberculosis, 

 particularly if the temperature reaches or exceeds 104° F. For 

 any rise less than this a repetition of the injection after four or 

 five weeks is highly desirable. In very rare cases the temperature 

 may rise in apparent absence of disease or it may fail to rise when 

 the tuberculosis is advanced and easy of physical diagnosis. 



For convenience in making the test the animals should not 

 be turned out, but fed and watered in the stable. It is desirable 

 to note the time of feeding and watering. 



MALLEIN. 



This agent is used as a diagnostic agent for Glanders 

 and Farcy in the same way that Tuberculin is used to diagnose 

 Tuberculosis. 



The dose depends upon the way in which the product is pro- 

 cured, i e. whether concentrated or diluted. It is printed upon 

 the vials. 



Only antitoxins and diagnostic serums from manufacturers 

 with the best reputations should be used. 



DIRECTIONS FOR USING MALLEINE FOR THE 

 DIAGNOSIS OF GLANDERS. 



Take the temperature of all animals to be tested three times 

 a day for one day before making injections. 



The injection is most conveniently made at six or seven 

 o'clock in the morning, and the maximum temperature will then 

 be reached by or before 10 P. M. of the same day. 



Make the injection beneath the skin of the middle of one 

 side of the neck, where any local swelling can readily be detected. 



Carefully sterilize the syringe after injecting each horse by 

 flaming the needle over an alcohol lamp. 



Take the temperature every two or three hours for at least 

 18 hours after the injection. Sterilize the thermometer in a 5 

 per cent solution of carbolic acid, after taking the temperature 

 of each animal. The temperature will begin to rise, as a rule, 

 within from 4 to 8 hours after the injection, and reach its maxi- 

 mum from 10 to 16 hours after injection. On the day succeeding 

 the injection take the temperature at least three times, if possible. 



