4i6 



SPECIFIC MICRO-ORGANISMS 



agar have been obtained by NicoUe and are easily propagated 

 at 22" C. Dogs and monkeys are susceptible to inoculation and 

 the human disease is probably contracted from dogs through 

 the agency of insects. The disease is relatively benign and recov- 

 ery is followed by prolonged immunity. Inoculation has been 

 practised in man in order to produce immunity. 



Fig. 174. — Leishmania tropica, 

 forms observed in cultures. (From 

 Doflein after NicoUe.) 



Pig. 175. — Trypanoplasma cy- 

 prini. Bl, Blepharoplast; N, nu- 

 cleus. X 2000. {After Dojlein.) 



Leishmania Infantxim.- — Nicolle in 1908 observed this organ- 

 ism in the spleen, liver and bone marrow of children dying from 

 splenomegaly in northern Africa. The disease resembles Kala- 

 Azar in all respects except that the patients are all very young. 

 Dogs are naturally infected with this parasite and are probably 

 the source of the human disease. Cultures on blood-agar are 

 readily obtained and kept up indefinitely without special difficulty. 



