285 ■ 



this = loo per cent. Dilute this solution, so that 

 a number of tubes equal to ninety, eighty, seventy, 

 etc., per cent, are" got. Compare the tubes con- 

 taining the salt solutions directlv with these. 



In malaria, the resistance of the blood is 

 markedly lowered, thus, whereas in a control 

 normal blood a o'4i per cent, salt solution gave 

 no haemolysis ; in the case of two malaria patients, 

 the haemolysis was equal to twenty-five per cent, 

 and forty per cent., respectively. 



In blackwater fever, on the contrary, a raised 

 resistance of the blood may be found. 



Clinical Study of Malaria 



The Urine. — While not proposing here to con- 

 sider the general reactions of the urine in malaria, 

 for which we must refer the reader to any standard 

 text-book, yet we think it useful to consider some 

 points which are of more particular interest. It 

 is especially in blackwater that we still require 

 complete analyses of the urine, and more especially 

 in those who are constantly subject to malarial 

 attacks and are at the same time taking quinine. 

 It is possible that such analyses might give us 

 indications which would enable us to avert the 

 danger of an attack of blackwater fever and to 

 determine when quinine should not be given. We 

 have not considered here the method of examining 

 the urine by ' cryoscopy,' as it is not at present a 

 practical clinical method, but its possibilities 

 should not be forgotten. 



Albuminuria. — The occurrence of albuminuria 

 in malaria varies according to the particular 

 country ; thus in Rome it is uncommon, in Senegal, 



