30I 



more likely that these irregular charts are produced 

 by an irregular irruption of young forms into^the 

 circulation than that the parasite has a variable 

 time of development. If we suppose that young 

 fission forms exist in the internal organs, but do 

 not commence their growth in the circulating red 

 cells, but come into the circulation irregularly, 

 then we should have still a constant time of de- 

 velopment, but an inconstant time at which the 

 development started. If, however, a quotidian 

 parasite exists, there should be no difficulty, as 

 we have stated above, in determining the fact by 

 a series of measurements at fixed intervals. 



Action of Quinine 



The data of different investigators into the 

 absorption and elimination of quinine exhibit 

 considerable differences dependent upon the dif- 

 ferent conditions of experiment and the mode of 

 estimation employed. The following statements 

 must therefore be received with caution : — 



1. According to Kerner the elimination of — 

 Quinine hydrochlorate begins in fifteen minutes 



and ends in forty-eight hours. 



Sulphate (neutral) begins in thirty minutes and 

 ends in forty-eight hours. 



Sulphate (basic) begins in forty-five minutes and 

 ends in sixty hours. 



2. Mode of Administration — 



Per OS, quinine appears in the urine in thirty to 

 fifty minutes. 



Per rectum, quinine appears in the urine in eighteen 

 to twenty minutes. 



