303 



7- Kleine's data as to the amount eliminated 

 in twenty-four hours : — 



Per OS Administration — 



(0 25-34 per cent. 



(ii) 1971 

 (ill) 27-29 



,^ . . i^V 9'67 



This low value, No. 4, is explained by the fact 

 that the quinine was given on a full stomach, 

 whereas in the three other results the quinine had 

 been given to the patient fasting. 



Now, although proportionately a smaller 

 amount is excreted in this way (and this is pos- 

 sibly in conformity with the clinical experience 

 that ringing in the ears and other unpleasant 

 symptoms of quinine are generally absent after 

 subcutaneous injection), yet it is probable that the 

 excretion is a more prolonged one than by the 

 other methods, for deposits of quinine can still be 

 found at the site of injection some weeks later, 

 and so the undoubted efficacy of this mode of 

 treament may really be due to its prolonged action 

 (and elimination). 



Mariani's results also shew that after an 

 injection of quinine into the muscles of a rabbit, 

 about twenty-four hours later, half the amount 

 could still be extracted from the muscles. Kleine 

 and Mariani's results shew that a full stomach 

 inhibits markedly the absorption of quinine, so 

 also any catarrhal state is prejudicial. 



