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PosT-MoRTEM Changes in Malaria 

 (Marchiafava and Bignami) 

 Brain : — 



1. Piinctiform haemorrhages of the men- 

 inges. 



2. Punctiform haemorrhages of the white 

 substance of the brain. 



3. The brain capillaries may contain nearly 

 every red cell infected. Sporulating forms are 

 especially common. 





Fig. 65, Shelving deposition of Pigment in Liver (left), 



Spleen {right), and Sporulating Parasites in 



Brain Capillary {bottom) 



4.. The capillary endothelium may showfatty 

 degeneration, together with pigmentation, and 

 sometimes parasites. 



5. Similar appearances are also found in the 

 vessel of the pia mater. 

 Lungs : — 



I. Large pigmented mononuclears in the 

 capillaries, but especially in the veins ; in the 

 lungs especially phagocytosis is proceeding. 



