The use of 2,4,5-Ton range, pasture, and forests or on rights of way and other non- 

 agricultural land is all right, but it should not be used near homes or recreation 

 areas. A review is being made of registered uses, to make certain that these include 

 adequate precautions against grazing in areas so that no contaminated meat or milk will 

 result. The mam concern is the length of time between treatment by 2,4 5-T and'eraz- 

 mg by animals. s 



While residues of 2, 4, 5-T in meat and milk are very rare, they are illegal and make 

 contaminated products subject to seizure. There is no tolerance for 2,4 5-T on meat 

 milk, or any other feed or food. 



The USDAwill issue guidelines for disposing of household products containing 2 4 5-T 

 llns chemical is biologically decomposed in a moist environment. 



Research in November and December, 1969, indicates that 2,4, 5-T has produced a number 

 of birth defects when fed or injected into certain strains of mice and rats, but the 

 birth abnormalities could not be attributed with certaintv either to 2 4 5-T or to 

 the impurities, dioxins, known to be present. Evidence of the extreme 'potency of the 

 impurities as toxic agents was shown, and the 2, 4, 5-T now being marketed is of greater 

 purity than that- which was tested. s 



Studies have been initiated to determine whether 2, 4, 5-T itself, its impurities, or a 

 combination of both caused the earlier findings, and whether the 2, 4, 5-T now being 

 marketed produces birth abnormalities in mice and rats. 



Taken separately the dioxin impurities and the 2, 4, 5-T, as it is now manufactured, both 

 produced birth abnormalities in the experimental mice. Because absolutely pure 2 4 5-T 



Hnnf thTii lable f °^ T fi ng ' J* iS ° nly P° ssible t0 infe r from certain of the observa- 

 tions that the pure 2,4 5-T probably would be teratogenic if tested. However, since 

 pure Z,4,5-T is not marketed and could not be produced in commercial quantities this 

 is not a practical issue for consideration. ' 



The measures being taken are designed to provide maximum protection to women during 

 the childbeanng years by eliminating formulations of 2, 4, 5-T from use in household 

 aquatic and recreational areas. Its use on food crops will be cancelled, and will be 

 controlled on range and pastureland. Maximum surveillance of water supplies and 

 marketed foods will be maintained, as a measure of the effectiveness of these controls 

 Details will be announced shortly in the Federal Register. 



TANK-MIXING HINTS 



Many herbicides are being applied with liquid fertilizers. Problems of compatability 

 sometimes arise when emulsifiable concentrates (EC's) are mixed with liquid fertilizers 

 because the emulsifier is not salt-stable. Some manufacturers have special, pesticidal 

 formulations for liquid-fertilizer application. Others specify the emulsion stability 

 beadde^if needed. * COmpatabilit y a S ent ^ such as Compax or Spento 68) should 



If you can determine dilution factors, you can check compatability in quart jars before 

 mixing a whole tank. First, determine the volume of spray per acre. With liquid 

 fertilizers, this will depend on the analysis used and the rate desired. Next, determine 

 the volume or weight of the pesticide to be applied per acre. Then, convert the number 

 oi quarts or pounds of additives and gallons of spray carrier to an amount per pint of 

 spray. Useful small measurement units are grams and milliliters. There are 454 grams 



