TETANUS. 119 



through the body and its elimination in the following 

 manner : 



Animals were poisoned by injections of the substance 

 prepared by TizzoNi and Cattani, and just before death 

 they were killed and bits of various organs rubbed up with 

 sterilized water wore injected into other animals. Emul- 

 sions from the liver and supra-renal capsules were invariably 

 without effect, while those from the kidney were constantly 

 poisonous. This is supposed to prove that the poison is 

 eliminated by the kidney. The blood taken from the vena 

 cava was found to be poisonous in three out of four experi- 

 ments. When the injections were made under the skin 

 the lumbar cord was active in four out of eight cases, and 

 in all, when the injections wore made directly into the 

 sciatic nerve. On the other hand, when the inoculations 

 were made under the dura mater, the brain was found to 

 be active while the lumbar cord remained inactive. From 

 these experiments it is concluded that the poison not only 

 circulates in the blood, but is deposited in the central 

 nervous system. 



A. Babes prepared, from cultures made by V. Babes 

 and PusCAEiA in agar containing no peptone, an albumose 

 which causes tetanus in animals. 



Faber finds in a mixed culture a poisonous proteid 

 body which resembles closely, so far as it has been studied, 

 that of TizzoNi and Cattani. Faber lays much stress 

 upon the arguments in favor of this substance being a 

 soluble ferment. With this proteid, convulsive movements 

 first appear and become very distinct in the muscles about 

 the point of injection. In case very small amounts are 

 employed, the convulsive movements do not become general 

 and the animal finally recovers. 



Peyraud claims to have secured immunity in animals 

 against "earth tetanus" by giving to them strychnia in 

 gradually increased doses. Nocaed could not confirm this 

 claim. 



According to Ledantes, the. poisonous arrows of the 

 natives of the New Hebrides are prepared as follows : The 

 points, which are usually made from human bones, are first 



