42 LEPROSY (BACILLUS LEPRAE) 



larity in shape than the B. Tuberculosis, being some- 

 times pointed and sometimes swollen at the extremi- 

 ties. All these differential characters are inconstant 

 and untrustworthy. Organisms corresponding to the 

 typical form and variants from that form may be 

 found in the photographs. 



All attempts to procure undoubted cultures and 

 successful inoculations with the supposed cultures 

 have hitherto failed. 



The most promising cultures have been obtained 

 by Bordone Uffreduzzi (Turin) from bone marrow, 

 and by Gianturco (Naples) from a non-ulcerated 

 nodule. These independent observers appear to 

 have isolated a bacillus which in morphology and 

 staining reaction resembled the B. Leprae of the 

 tissues, and was not B. Tuberculosis. The bacillus 

 isolated by Uffreduzzi is depicted in Fig. 36, and is 

 characterised by the extreme segmentation and the 

 swelling of the extremities. In late sub-cultures the 

 specific staining reaction appears to be lost and the 

 bacillus presents such branched forms as are seen in 

 Fig. 14. These branched forms also occur in cultures 

 of B. Tuberculosis. 



Attempts to inoculate directly from the diseased 

 tissues, whether in man or in animals, have not been 

 much more successful than the attempts with 



