BACILLUS TYPHOSUS 



Discovered and described by Eberth in 1880, the 

 B. Typhosus was isolated and its causal relation to 

 enteric fever proved by Gaffky in 1884. 



In sections of the spleen, liver, or swollen 

 mesenteric glands of patients dead from enteric 

 fever, especially in the earlier stages of the disease, 

 are found scattered rather large colonies of bacilli, 

 easily seen with a low power and having frequently 

 an arterial distribution. The tendency of the bacilli 

 to collect into colonies in the organs is a marked 

 feature of the B. Typhosus, and is shown in Fig. 50, 

 which represents a section through a mesenteric 

 gland. The two large dark patches are the colonies 

 of bacilli. In the internal organs, as a rule, the 

 colonies are not associated with much change in the 

 surrounding tissues, but in the intestine inflamma- 

 tory and necrotic alterations are the rule. 



The tissue round the colonies of Fig. 50 is 

 necrosed and has lost all power of staining. 



