1 to 8 or 9 per cent. Lee’s investigation (Jowr- 
nal of Physiology, 1908, p. 885) found that 
about half of the total nicotine was present in 
the smoke—according to Lee the pyridin seemed 
to be entirely without influence. 
Lehmann (Archiv fiir Hygiene, 1909, p. 819) 
found that from 80 to 90% of the total nicotine 
in a cigar or cigarette was to be found in the 
smoke. He found also that in the case of cigars 
about 10 to 18% of the nicotine in the smoke 
is absorbed by the smoker and that cigarette 
smoke absorbed by the smoker contains a less 
proportion of the nicotine in the tobacco than 
is the case with cigars. The general opinion 
is, however, that about one-seventh of the nico- 
tiue in the tobacco will be found in the smoke. 
Entirely at variance with these results are 
those obtained recently by A. D. Bush, M.D., 
Instructor of Physiology in the University of 
Vermont (New York Medical Journal, March 
14, 1914), and those obtained in the laboratory 
investigation by the London Laucet. Bush 
made long and extensive investigations on the 
effects of tobacco smoking and criticised the 
results of previous workers. He shows very 
clearly that in many cases the conclusions 
drawn by them as regards nicotine contained in 
tobacco smoke are either entirely erroneous or 
that the deductions made from the investige- 
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