GLYCOSURIA IN SOLIPEDS. 



Heiss records two cases of this disease in heavy Belgian horses 

 ten and eleven years old, the urine of which showed a percentage 

 of 3-75 of grape sugar, and which died in two months in a state 

 of marasmus. The liver was enlarged and of a clay yellow color. 

 Dieckerhoff reports one fatal case in which there were also yellow 

 discoloration, conge.stion and hypertrophy of the liver. No lesion 

 could be found in the pancreas nor nervous system. Perosino 

 records a case in a horse suffering from contagious adenitis, 

 which may be suppo.sed to have been connected with the action 

 of the toxins or the imperfectly oxidized albuminoids on the 

 nerve centres or liver. Delprato relates six cases in the same 

 stable in overworked, half starved and emaciated horses. 

 Ruefl and Mouquet each contributes a case occurring in para- 

 plegia attendant on hsemoglobinuria and in which the amounts 

 of sugar were respectively 5.85 and i.oi per cent. These latter 

 cases are manifestly complicated ones in which the reflex irrita- 

 tion (or inhibition of glycogene.sis) is transmitted from the dis- 

 eased or poisoned brain to the already disordered liver. 



Symptoms. There is a profound interference with nutrition, 

 a rapid loss of flesh and weight, of .spirit and energy and an ex- 

 treme muscular weakness in spite of an excessive appetite. The 

 subject is fatigued and breathless under the slightest exertion, 

 the flanks are retracted and hollow, and the hair dry, rigid and 

 lifeless. Appetite is poor and fastidious, but an intense and con- 

 suming thirst is usually present, the animal drinking deeply at 

 every opportunity, and passing urine with corresponding fre- 

 quency and abundance. The urine is clear, yellow, neutral, and 

 saccharine, the sugar varying from i to 12 per cent. (3.6 on an 

 average). Notwithstanding the amount passed (55 litres per 

 day, Cadeac) the density usually exceeds the normal (1052 and 

 upward), normal being 1040 to 1050. There may or may not be 

 hyperthermia, and in exceptional cases appetite has been retained 

 to the last. Cataract and corneal ulceration are sometimes ob- 

 served as in man. 



Diagnosis. Presumption may arise from the above mentioned 



i.2l 



