448 Veterinary Medicine. 



valuable hints as to the lines of inquiry that may be followed 

 with the best hope of reaching definite results. 



Lesions. These are especially found in the blood, liver, spleen, 

 muscles, bone-marrow and kidneys. The spinal cord and nerve 

 trunks are occasionally affected. 



The blood is charged with carbon dioxide and is black, tarry, 

 comparatively incoagulable remaining in the veins and .showing 

 an irridcscent reflection. It does not absorb oxygen readily 

 though exposed to the air, and thus bears a strong general 

 resemblance to the blood of anthrax. It contains an abnormal 

 proportion of urea and allied extractive matters which greatly 

 increase its density, and interfere with the healthy exercise of 

 the different cell organisms and functions. These are not due to 

 exce,ssive muscular activity as stated by Friedberger and Frbhner, 

 but are derived mainly from the abundant products of digestion. 

 When the shed blood coagulates it forms a soft clot without buff 

 and the expressed serum is reddish from the presence of haemo- 

 globin, and of hsematoidin cry-stals. The uncoagulated blood 

 drawn over a sheet of white paper stains it deeply by reason of 

 the same coloring matters in solution. The red corpuscles may 

 be paler than natural, .some even entirely colorless, and they are 

 often notched or broken up in various irregular forms. They 

 have lo.st the natural tendency of the shed equine blood to stick 

 together, to collect in rouleaux and precipitate to the bottom of 

 the vessel, so that no buffy coat is formed, should the blood 

 coagulate. The white corpuscles are relatively increased. Fin- 

 ally the coloring matters contained in the plasma are imbibed by 

 the different tissues and give a brown or reddish tinge to such as 

 are naturally white. Limited blood extravasations are not un- 

 common especially in the more vascular organs like the muscles, 

 liver, spleen and kidneys. 



The liver is more or less congested and enlarged, friable, yellow, 

 or mottled yellow and red and exudes black blood freely when 

 incised. The bile is thick, vi.scid and dark green, as in cases of 

 experimental intravenous injection of haemoglobin. 



The spleen is also swollen and congested with blood, and the 

 pulp is very high colored from the excess of haemoglobin and 

 other products of blood destruction. The muscles of the croup 

 are usually the seat of visible lesions. There may be pallor. 



