Amyloid Degeneration of the Spleen. 563 



of blood highly charged with the melanic matter is not uncom- 

 mon. 



The symptoms of the splenic deposits are not usually recog- 

 nizable, but indications of chronic abdominal disease in connection 

 with external melanotic formations may well lead to a reasonable 

 suspicion. 



Angioma. In a horse^ s spleen weighing 30 lbs., there were 

 numerous soft nodules of a deep cherry color. These were 

 cavernous masses with connective tissue walls and the meshes 

 filled with blood. 



Similar vascular cavernous tumors have been found in the cow. 



Lympadenoma has been found in the spleen of horses and cattle 

 in connection with the same disease of the lymph glands. 



I,ike the other splenic tumors this is obscure and usually only 

 found after death. The existence of adenoid swellings elsewhere 

 conjoined with excess of white globules and indications of abdomi- 

 nal pain would be suggestive of splenic disease. 



AMYLOID DEGENERATION OF THE SPLEEN. 



Amyloid : horse : with exhausting diseases. Waxy secretion staining 

 mahogony brown with iodine. Gangrene : Swine. Tubercle and glander 

 nodules. 



This has been occasionally detected in the spleen of the horse. 

 It is usually connected with longstanding suppuration especi- 

 ally of bones, with advanced tuberculosis or other exhausting 

 disease. The organ is usually greatly enlarged and the affected 

 parts are firm, resistant and swollen. On .section it has not the 

 soft friable or pulpy appearance of the spleen, but an uniform 

 waxy looking, consistency, grayish or sometimes stained with 

 blood. On the application of a solution of iodine and iodide of 

 potassium the healthy splenic tissue is colored yellow, while the 

 amyloid portion becomes of a deep mahogany brown. 



