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chemical noxious products. It thus appears that Koch's granules have 

 been found in normal kidney smears. This is not in accordance with the 

 result of the examination of smears from normal kidneys of cattle carried 

 out by the writer for the purpose of ascertaining whether the bodies 

 referred to by Koch were present in normal kidney and spleen smears 

 of cattle. A number of each were examined ; in all cases the results were 

 negative. On the contrary the examination of a considerable number of 

 smears of spleens of East Coast fever cattle sent in from different 

 districts of the Transvaal always gave positive results. The writer has 

 observed during the course of a microscopical examination of a number 

 of normal smears from cattle minute reddish coloured granular bodies 

 which are found scattered throughout the smear in some cases; in other, 

 arranged in groups. In some instances they appear to be contained 

 within a cell wall, in which case they resemble somewhat the appearance 

 presented by blood plates in normal blood. They differ from Koch's 

 granules in size and also staining reaction. 



The constant presence of Koch's granules in the lymphatic glands, 

 in the kidneys and spleen of animals affected with East Coast fever affords 

 a means of basing a diagnosis in those cases, in which, as already pointed 

 out, a microscopical examination does not permit of this. The presence of 

 these granules in the lymphatic glands, kidneys, and spleen is specific 

 for East Coast fever. The Bacteriological Laboratory make use of the 

 fact for the definite diagnosis of all doubtful cases of infection with small 

 piroplasms. 



