109 



of haemolysis congested, very often soft, friable, enlarged, in the majority 

 of instances jaundiced, brownish or greenish discoloured with an 

 increased quantity of bile. 



4. Kidneys. 



Haemoglobin is noxious to the kidneys. Parenchymatous degenei'a- 

 tions of these organs were observed after haemolysis due to the injection 

 of distilled water (own experiment), in haemoglobiniiria paroxysmalis 

 hominis in the haemogiobinuria paralytica of horses (lumbago), in all 

 diseases which occur with haemolysis, and finally in cases of haemolysis 

 after injection of isolytic serum. In cojinection with this "serum 

 disease " the following lesions were recorded : — Adherent eapsula, 

 congestion and dark appearance of the paremchym, abnormal size and 

 weight, oedema and frialnlity, dark radial stripes. 



Examples* : Horse 297. — Injected on Gth July, 1903, with serum 

 of horse 147. This animal showed similar symptoms as those described 

 in horse 298. It was better the next day (7/7/03), but would not eat. 

 On 8th July, 1903, haemogiobinuria was noticed for the first time. The 

 mucous membranes were yellow. There was loss of condition. The 

 animal laid down almost the whole of the 9th July, 1903. 



Horse 297 died on 9th July, 1903. Post-mortem was made one hour 

 and a half after death. The condition of the animal was good. Rigoi' 

 mortis was present. There was a general jaundiced condition of the 

 flesh and the serous membranes. The blood was coagulated and 

 separated into black and white clots : the plasmatic clot had a some- 

 what brownish hue. The heartbag was filled with dark yellow liquid. 

 The heart muscle was pale. There were no echymosae on the endocard. 

 The liver was dark green in colour. The spleen was enormously 

 enlarged, its weight being 12 pounds ; the puljpa was soft. The kidneys 

 were uniformly dark red, with haemorrhagic infarcts in the cortex. 

 The urine was black. The mucous membrane of the stomach was 

 covered with blackish mucous (coagulated blood). The intestines were 

 normal. 



Horse 298.— Injected on 6th July. 1903, with serum horse 147. The 

 injection was made into the lower part of the jugular vein. Soon after 

 injection the horse lost control of the hind quarters, staggered for a few 

 minutes, and dropped suddenly, neighing repeatedly. The pulse was 

 rapid, the respiration was accelerated. After a lapse of a few minutes 

 the horse rose again : it now kept the head stretched out ; it breathed 

 quickly with wide open nostrils. In the afternoon of the same day the 

 horse went down again. It showed tremor of the muscles ; it moaned 

 and had a rapid respiration. The next day (7/7/03) horse 29S seemed to 

 be better. On the 8th July, 1903, horse 2f».S lay down again. The 

 mucous membranes had a yellowish colour. The horse tried to stale 

 repeatedly. Red urine was voided. The animal lost condition from 

 day to day until death. 



Horse 298 died at 1 o'clock p.m. on 10th July, 1903. Post-mortem 

 was made one hour later. The condition of the cadaver was fair 



Copied from Ann- Eep. Govt. Vet. Bact., 1903-04. 



