147 



the opposition of connective tissue to the lymph vessels, a great thickening 

 of the pleura appears, which gradually goes over into the thickened inter- 

 stities of the lobuh. 



The adjacent alveoli are in the stage of carnification, or have only 

 reached stage one of pneumonia. 



Contrary to what was seen in the interstities, there is a very great 

 number of lymphocytes in the spaces of the tissue, which must be regarded 

 as emigrants from the small subpleural lymphatic glands. 



Peritoneum. 



Almost the same lesions were found in the peritoneal walls of a sero- 

 fibrinose peritonitis which was experimentally produced by intraperitoneal 

 injection of a pleuro-pneumonia culture. Another specimen was taken 

 from case 9, which will be described below with its macroscopic lesions. 

 The stages observed by me had strong infiltration and regeneration of 

 the intermediate layers. In some places in the peritoneum granulation 

 tissues are found, the membrana propria and the endothehal layer have 

 disappeared ; instead of them there is a layer of fibrine undergoing 

 organisation, just as in the pleura. The subserosa and its lobules of fat 

 are extremely rich in capillaries and foci of infiltration ; margins of 

 leucocyte emigrants are very frequent. The quantity of plasma cells is 

 more than normal. 



I beheve that I am right in stating that the action of pleuro-pneumonia 

 virus on serous membranes is the same as on the interstities of the lungs, 

 and that the lymph spaces and lymph vessels are the starting point of 

 the inflammatory process, in which all stages of lymphangitis can be 

 observed. 



I will now qxiote several post-mortem reports, material collected at 

 which serve as basis for further histological investigations. It will be 

 shown that inflammatory processes of the nature of pleuro-pneumonia 

 can establish themselves in the muscles, in the subcutaneous connective 

 tissues, in the capsules of joints and in the synovialis, these processes 

 being really specific of the disease. 



CASE 1. — Ox 671 was injected for experimental purposes in the right 

 side of dewlap with two different vira, originating from two different 

 spontaneous cases, separated in time and locality, but both from the 

 Transvaal. The animal was slaughtered on the 16th day, a large 

 oedematous swelling having appeared at the site of injection. 



Post-mortem Report : On the right side of the dewlap, from the 

 spina scapulae to the fourth cervical vertebra and on the left side to the 

 fossa jugularis is a huge swelling. The skin over the sweUing is drawn 

 tight ; there are excoriations and bald patches at the bottom of the dew- 

 lap. The tumour is hard, very turgescent. Impression of the finger leaves 

 a distinct pit in some places. On section a large quantity of hmpid 



