In South Africa there are strains of cattle which, when inoculated 

 with pleuro-pneumonia vaccine, invariably succumb to a rapid progressive 

 lymphangitis and peritonitis. The practitioner must help nature by 

 cauterising the skin around the tail above the swelling caused by injection, 

 thus causing an acute inflammation of the blood vessels and stopping the 

 disease from progressing towards the body of the animal. Another proof 

 that the virus does not follow the blood vessels, for if it did, we would 

 expect that it would be favoured by the inflammation. Contamination 

 of the virus with bacteria can be shown to be of httle importance ; from 

 a vaccine which produced absolutely local lesions, no less than twelve 

 species of bacteria were isolated. 



The Microscopical Lesions in the Musculature. 



Pieces of muscles of cases 1, 3, 4, and 6 were examined. In order 

 to obtain comparable specimens, sections were made in each case of the 

 musculus sternodeidomastoideus, preparations of other muscles were also 

 made, especially when the macroscopic lesions were in any way remark- 

 able. The flrst changes observed in any muscle axe the great thickening 

 of the subfascial connective tissue, the next alteration observed is that 

 the perimysum externum becomes involved ; here one remarks bands of 

 a flnely fibrillar tissue, which all stain with the acid components of the 

 tinction employed, and which can to some extent be demonstrated by 

 fibrine staining, crossing and recrossing the field of vision. In this spongy 

 coarsely reticulated tissue one remarks isolated deep staining complexes, 

 these last usually contain rarely ramified blood vessels distended with 

 blood corpuscles. The vessels are surrounded by polynuculear leucocytes 

 which are arranged radially around their axis. The size of the radius 

 is remarkably constant, it averages 50 i«. On the edges of such complexes 

 the intermediate fibrine condenses to form a dense layer. In the meshes 

 of the fibrine the polynuclear leucocytes readily break up ; in older stages 

 karyorhexis is very pronounced. The blood vessels are still perfectly 

 normal at this stage, except perhaps that the intravascular leucocytes 

 collect towards the walls and a shght diapedesis of the erythrocytes is 

 taking place. The perimysium is not alone the starting point of the 

 inflammatory processes in the muscles ; the secondary muscle fasciles are 

 strongly invaded by leucocytes on their surface where they are in contact 

 with morbid tissue of the perimysium internum. The invasion proceeds 

 gradually towards the centre ; however, one sometimes finds places 

 where leucocytes crowding in between the secondary fasicles towards 

 the centre, surround a capillary and there produce the usual lesions. It 

 is remarkable that each muscle fibrilla is separated from its neighbours 

 by a typical finely fibrous tissue. Here and there are places where the 

 muscles have entirely atrophied, their former presence being indicated 

 by the hollows they have left behind. Those fasciles of the muscle Iving 



