158 



Clinical Symptoms: Fourteen days after injection a large swelling 

 was observed 10 cm. from the tip of the tail; on the 16th day the tumour 

 had progressed past the base of the tail and invaded the perianal tissue. 

 (See figure.) The anal mucosa was oedematous and painful, causing 

 incessant straining. Both anal lymph glands were swollen and hard. 

 It may here be mentioned that twenty-six control animals only showed 

 local lesions. Killed shortly before death. 



Post-mortem Report : Body in fair condition; tail greatly swollen, 

 skin of basal portion with many cracks, resembles bark. A large tumour 

 extends from the base of the tail to the regio pubica. Anus open, mucosa 

 jelly-like, with small superficial haemorrhagies. The subcutaneous 

 connective tissues form a tough layer containing large cavities, from which 

 a yellowish hquid flows which coagulates slowly. The tissue extends to 

 themusculus glutaeus, semimembranosus and semitendinosus, both muscles 

 having their perimysium internum extensively thickened. The lymph 

 glands on the tubera ischiadica are enclosed in a dense envelope of connec- 

 tive tissue, closely attached to the capsule. The glands, which equal 

 a hen's egg in size, are sappy on section. From here, the oedematous 

 infiltration extends to the sphincter ani, passes upwards to the musculus 

 bulbo-cavernosus and ischiocavernosus, and disappears gradually in an 

 oedema of the subcutis or near the middle of the crura. The pelvic cavity 

 has following lesions. The urinary bladder projects into the peritoneal 

 cavity, surrounded by a thick ring of oedematous fat tissue, its diameter 

 is more than 30 cm. The serosa, the lower portions of the excavatio- 

 rectovesicalis and the parietal folds of the pelvis are covered with a dense 

 coating of fibrine, or with fibrous fibrine. The cervix vesicae is connected 

 to the rectum by a mass of fibrine. The ligamenta lateralia vesicae are 

 2 cm. thick and deeply covered with fibrine. The peritoneum is either 

 diffusely hyperaemic or shows arborisation of the capillaries. The bladder 

 contains 3 litres of a clear, dark yellowish urine. The mucosa of the 

 trigonium lieutaudii is slightly oedematous and contains haemorrhagic 

 spots. The urethra is shghtly dilated before the obstruction, its mucosa 

 is slightly swollen and streaked longitudinally. At the colhcus seminalis 

 the pressure of the oedematous fibrinous perianal fatty tissue closes the 

 urethra. The mucosa is pale, with a few ecchymoses. The whole urethra 

 and its corpora cavernosa are covered with a spongy tissue of fibrous 

 character. The left kidney is raised out of the capsule fat, weighs 920 gr., 

 some of the lobuh are irregularly swollen, the corresponding urethra 

 is slightly dilated. The capsule strips easily ; in one of the middle lobuli 

 is an irregularly outlined yellowish-white patch 7 cm. broad, carrying 

 in its centre a few haemorrhagic patches. This part proves on section to 

 be an infarct, with a remarkably strong injection of the glomeruli. 

 The cortex of the other parts of the kidney is oligaemic, the medulla 

 alone is slightly/ congested. In the slightly flattened papillae: renales 

 whitish-yellow stripes converge towards the apex of the papillae. 



