OPERATIONS ON THE MOUTH, PHARYNX, ETC. 131 



and it has been for a long time well known that when once 

 the}' appear amongst large kennels of puppies (such as fox- 

 hounds) the\' spread \\ith great rapidity. This is probably 

 owing to the habit puppies have, ^\'hen pla}'ing, of catching 

 hold of one another's mouths. A scratch or small abrasion 

 of the mucous membrane is necessary for infection. 



The main details of the observations aUuded to are as follows : On 

 August 13, 1898, the cut surface of a wart, just excised with sterile instru- 

 ments from the buccal mucous membrane of a young foxhound, in which 

 the lining membrane of the mouth was absolutely covered with growths, 

 was used to rah a small area of abraded mucous membrane on the right 

 tipper lip of each of 

 three dogs — a pug and 

 two fox-terriers. No- 

 thing was noticed for 

 about a month, when 

 in each of the terriers 

 a very small growth 

 began to show itself 



After six weeks a 

 minute elevation was 

 observed on the scari- 

 fied spot on the pug. 

 In the two fox-terriers 

 the papillomata con- 

 tinued to increase until 

 about June 10, when 

 they had attained an 

 appearance identical 

 with those of the 

 natural warts in the 



mouth of the foxhound. They remained like this for about a week and 

 then began to shrink, and by the 28th had almost entirely disappeared. 

 The warts on the lip of the pug grew rather more slowly. On June 30, 

 when the animal was destroyed by chloroform, they had the size and 

 appearance shown in Fig. loi. On June 30 one of the experimental 

 warts was snipped off with sterile scissors and gently rubbed over a 

 small area of scarified mucous membrane on the left side of the upper 

 lip of each of the same fox-terriers and on both sides of the upper lip of 

 a bull-terrier. Papillomata formed at the scarified spot on each side of 

 the bull-terrier's lip ; they were perceptible on August 2, and grew until 

 about the 26th, and by September 6 had almost entirely disappeared. In 



9—2 



Fig. lor. — Head of Pug showing Warty Growths 

 at Seat of Inoculation on Right Upper Lip. 



