MICROCOCCUS INTRACELLULABIS 361 



In addition to its presence in the meningeal exudation 

 of epidemic cerebrospinal meningitis, this organism may 

 appear as a secondary invader of the lung, causing more or 

 less extensive pneumonic exudation; of the joints; the ear; 

 the eye; and the nose and throat. Though rarely, its 

 presence in the circulating blood may sometimes be demon- 

 strated (Gwynn). 



Subcutaneous inoculation with pure cultures has usually 

 no effect. Injections into the great serous cavities may or 

 may not result in serofibrinous or fibrinopurulent inflam- 

 mation. Positive results are oftener obtained on young 

 guinea-pigs weighing about 150 grams, than on larger, 

 more mature animals. Intravenous inoculations are equally 

 unsatisfactory, though the results depend upon the original 

 virulence, the age of the culture and the animal selected. 

 In horses toxic symptoms are often the conspicuous result of 

 this mode of inoculation. 



The only successful attempts to reproduce the morbid 

 conditions from which the organism is obtained are those 

 in which the living cultures have been injected directly 

 into the meninges. Weichselbaum produced congestion 

 with pus formation in the meninges of dogs and rabbits by 

 direct injection through openings niade in the skulls; Coun- 

 cilman, Mallory, and Wright caused the death of a goat by 

 the injection into the spinal canal of 1 c.c. of a bouillon 

 suspension of a pure culture of the organism, the autopsy 

 revealing intense congestion of the meninges of both brain 

 and cord, with slight clouding of the meninges and slight 

 increase of meningeal fluid, and Flexner^ succeeded, through 

 injections of cultures into the spinal canal of monkeys, in 



' Jour. Exp. Med., 1907, ix, 168. 



