384 APPLICATION OF METHODS OF BACTERIOLOGY 



scopically. If death ensue, it will, in all probability, be the 

 result of one of the three following types of infection: 



o. Septicemia resulting from the introduction into the 

 tissues of bacterium pneumonice. 



b. A less active form of septicemia resulting from the 

 introduction of sarcina tetragena, an organism frequently 

 seen in the sputum. 



c. Local or general tuberculosis. 



SPUTUM SEPTICEMIA. BACTERIUM PNEUMONIAE 

 (WEICHSELBAUM), MIGULA, 1900. 



Synonyms: Diplococcus pneumoniae, Weichselbaum, 1886; Pneumo- 

 coccus, Frankel, 1886; Micrococcus of sputum septicemia; Diplococcus 

 lanceolatus; Streptococcus lanceolatus; Streptococcus pasteuri; Micro- 

 coccus lanceolatus. 



If at the end of twenty-four to thirty-six hours the animal 

 be found dead, we may reasonably predict that the result 

 was produced by the introduction into the tissues of the 

 organism of sputum septicemia above mentioned, viz., 

 bacterium pneumonice, which is not uncommonly found in 

 the mouths of healthy individuals as well as in other con- 

 ditions. 



Inspection of the site of inoculation usually reveals a 

 local reaction. "This may be of a serous, fibrinous, hemor- 

 rhagic, necrotic, or purulent character. Frequently we may 

 find combinations of these conditions, such as fibrino-puru- 

 lent, fibrino-serous, or sero-hemorrhagic."^ The most con- 

 spicuous naked-eye change undergone by the internal organs 

 will be enlargement of the spleen. It is usually swollen, but 

 may at times be normal in appearance. It is sometimes 



'Welch, Johns Hopkins Hospital Bulletin, December, 1892, vol. iii. 

 No. 27. 



