CHAPTER XXI. 



Tuberculosis — Microscopic Appearance of Miliary Tubercles — Diffuse 

 Caseation — Cavity-formation— Encapsulation of Tuberculous Foci — 

 Primary Infection — Modes of Infection — The Bacterium Tuberculo- 

 sis — Location of the Bacilli in the Tissues — Microscopic Appearance 

 of Bacterium Tuberculosis — Staining Peculiarities — Organisms with 

 which Bacterium Tuberculosis may be Confounded: Bacterium 

 Leprae; Bacterium Smegmatis — Acid-proof Bacteria — Bacterium Tu- 

 berculosis Avium — Variations — Pseudotuberculosis — Susceptibility of 

 Animals — Tuberculin — Vaccination Against Tuberculosis — Actino- 

 myces Bovis — Actinomyces Israeli, Actinomyces Madurae, Actino- 

 myces Farcinious, Actinomyces Eppingeri, Actinomyces Pseudotuber- 

 culosis. 



BACTERIUM TUBERCULOSIS (KOCH), MIGULA, 

 1900. 



Synonym: Bacillus tuberculosis, Koch, 1882. 



Local or General Tuberculosis. — ^Should the animal 

 succumb to neither of the infections just described, then 

 its death from tuberculosis may reasonably be expected. 



When this disease is in progress alterations in the lym- 

 phatic glands nearest the site of inoculation may be detected 

 by the touch in from two to four weeks. They will then be 

 found enlarged. Though not constant, tumefaction and 

 subsequent ulceration at the point of inoculation may be 

 observed. Ptogressive emaciation, loss of appetite, and 

 difficulty in respiration point to the existence of the general 

 tuberculous process. Death ensues in from four to eight 

 weeks after inoculation. At autopsy either general or local 

 tuberculosis may be found. The expressions of tuberculosis 

 are so manifold and in different animals vary so widely the 

 (404) 



