CHAPTER XXII. 



Glanders — Characteristics of the Disease — Histological Structure of the 

 Glanders Nodule — Susceptibility of Different Animals to Glanders-^ 

 The Bacterium of Glanders; Its Morphological and Cultural Pecu- 

 liarities — Diagnosis of Glanders — Mallein. 



The disease is generally known as glanders when the 

 mucous membrane of the nostrils is affected, and as farcy 

 when the subcutaneous lymphatics are the principal sites 

 of involvement. 



Though most commonly seen in the horse and ass, 

 glanders is not rarely met with in other animals, and 

 is occasionally encountered in man. When occurring 

 in the horse its primary seat is usually upon the mucous 

 membrane of the nostrils. It appears in the form of 

 small gray nodules, about which the membrane is con- 

 gested and swollen. These nodules ultimately coalesce to 

 form ulcers. There is a profuse slimy discharge from the 

 nostrils during the course of the disease. The primary 

 lesion may extend from its seat in the nose to the mouth, 

 larynx, trachea, and ultimately to the lungs. Its secondary 

 manifestations are observed along the lymphatics that com- 

 municate with the initial focus; in the lymphatic glands, and 

 as metastatic foci in the internal organs. 



Less frequently the disease is seen to begin beneath the 

 skin, particularly in the region of the neck and breast. When 

 in this locality the subcutaneous lymphatics become in- 

 volved, and are converted into indurated, knotty cords — 

 "farcy-buds" — easily discernible from without. 

 (444) 



