THE MICROBES OF HUMAN DISEASES. 193 
always hypertrophied and softened in typhoid patients. 
The round red spots which may be observed upon the 
skin are distinctive marks of the affection of the diges- 
tive canal, and it has occurred to Bouchardat that if, as 
he supposes, these spots contain the same microbe as that 
of the intestines, it might be cultivated and attenuated 
into a true vaccine. 
The presence of special microbes in typhoid fever 
was first observed by Recklinghausen in 1871, but the 
exact description of the typhoid bacillus has been only 
recently given by Eberth and Klebs. 
Eberth has observed this bacillus in the spleen, 
the lymphatic glands, and the intestines, making 
use of special staining processes. It appears in the 
form of short rods with rounded extremities, in the 
tubular glands and round the bottom of these glands, 
which cover the mucous membrane of the intestine. 
They are numerous when the ulceration of Peyer’s 
glands begins; afterwards they become fewer, and 
are succeeded by other microbes. From the position 
of the bacteria in a section of the mucous membrane, 
it may be seen that they penetrate through its surface, 
and fasten on the ulcerated and mortified tissue 
(Cornil). 
Blood taken from living patients often displays 
bacilli amid the red corpuscles (Fig. 86). The spleen, 
which is always hypertrophied, contains the same 
bacillus, which is also found in the liver, and some- 
times in the kidneys and urine. 
