PREVENTIVE INOCULATION 65 
obvious reaction, the operation should be repeated after 
the lapse of a fortnight or three weeks. In this case a 
double dose of vaccine should be used, and as a matter 
of precaution the second injection should not be made 
at the same place as the first.” 
Twelve months later, however, Mr. Sewell repeated 
his experiments with Copeman’s vaccine, but unfortu- 
nately fared no better than upon his first attempt. Messrs. 
Hobday and Ridler, F. and M.R.C.V.S., carried out an 
observation, in which six fox-terrier puppies were vac- 
cinated, two of them with Copeman’s product, and the 
results were as follows: . 
Case 1.—March 23, 3 p.m.: Fox-terrier, male, three 
months old, fair condition; vaccinated with 45 minims 
subcutaneously in the thigh. Temperature, 102° F. 
9g p.m.: Very dull, back arched, as if in pain, and cold. 
Temperature, 102°4° F. 
March 24: No appetite; very tucked up flank, stiff, 
and disinclined to move. Weight, 3 lbs. 12 ozs. Tem- 
perature, 103° F. at 7 a.m. and 102°6° F. at 7 p.m. 
March 25: Found dead at 6.30 a.m. 
Weight of carcase, 3 lbs. 9 ozs. 
Case 2.—March 23, 3 p.m.: Fox-terrier, female, three 
months old, good condition; vaccinated by injecting 
30 minims subcutaneously inside the thigh. Tempera- 
ture, 102°4° F. 
gp.m.: Very dull, back arched, off feed, and not in- 
clined tomove. Temperature, 104° F. 
March 24: Evidently very ill. Weight, 43 lbs. Tem- 
perature, 102° F. Swelling at seat of vaccination. 
March 25: Drank a little milk; very lame, and looked 
very ill. Temperature at 7 a.m., 102° F., and at 6 p.m., 
103°4° F. Swelling at seat of vaccination. 
March 26: Large wound inside thigh, quite 1} inches 
long, where swelling had burst. Animal went about on 
three legs. Temperature, 105° F. 
From this date the dog seemed better, gradually 
acquired use of her legs, and regained her appetite; 
5 
