72 CANINE DISTEMPER 
increased accordingly, allowing 1 c.c. for each 20 lbs. of 
weight. It is probable, however, that this dosage is too 
small, and just recently Ferry has definitely recom- 
mended an increase* (see letter on p. 75). Injections 
may be made at three to four day intervals, increasing 
each dose according to the condition of the patient. 
Curative treatment should be pushed more gradually 
than the prophylactic treatment as a general rule. 
A suggested schedule of dosage for a 20-lb. dog is as 
follows : 
i} 
Of Mixed Bacterin, As Prophylactic. As Curative. ; 
Liquid. Tablets. Liquid. Tablets. 
First dose wis .. | TOCC. or 2 o25 cc. or 4 
Second dose... sao MSC, <b - 3 o5cc. 4 
Third dose ae se) SHCCs 3 5 I'0 c.c. i 
| 
increasing the curative doses by o's c.c. or one tablet. 
Half the above doses should be given to small dogs and 
puppies, and the latter should receive further doses 
six months later. With each prophylactic dose of the 
bacterin it is advantageous to give 5 c.c. of anti-distemper 
serum, as this supplies immunising bodies similar to 
those found in the blood of a dog that has safely re- 
covered from distemper. If it is definitely known that 
the dog has been exposed to infection, it is essential 
to give 10 c.c. of the serum with each dose of bacterin. 
Reaction to the Bacterin.—A certain degree of reaction 
may follow the injection, or a sick dog may appear to be 
worse and the symptoms more pronounced This re- 
action or “negative phase” should not cause alarm or 
the discontinuance of treatment ; it is an indication that 
the animal organism is responding to the treatment. If 
* An intimation has just been received from Detroit that the Canine 
Distemper Mixed Bacterin is being made four times the strength of 
that now being supplied, and the doses will be reduced to half, the net 
result being doses double the present strength, 
