Inflammation and Fever. 1 3 



and thus, day by day, the edges of the adjacent healthy 

 skin are drawn in, so as to cover the wound more or less 

 perfectly, and a slight scar only is left when healing has 

 been accomplished. 



Granule Corpuscles and Masses. This is another de- 

 generative transformation in lymph and, is seen mainly in 

 inflamed glands and brain- and lung-tissue. The cells found 

 in the exuded lymph are made up of granules x^^f inch in 

 diameter, and besides these, large, irregularly shaped masses 

 of granules are extended along the capillary blood-vessels. 

 After the lymph has coagulated these granular masses soften 

 and liquefy preliminary to re-absorption and removal, and 

 the restoration of the tissue to a healthy condition. When 

 in excess this softens and disintegrates the tissues, leading 

 to permanent loss of substance. 



Development of Lymph into Tissue. This is equivalent 

 to what takes place in the formation of the feac of the 

 abscess or of granulation-tissue. The liquid lymph in co- 

 agulating, becomes fibrillar, and the exuded cells and nu- 

 clei and those of the adjacent tissue, having an abundant 

 supply of blood and nutriment, multiply first as simple, 

 rounded embryonic cells, then deposit around them new 

 tissue, becoming elongated, spindle-shaped, branching, etc., 

 and thus get imbedded in a fibrous material of their own 

 formation. These new formations are usually of a low type 

 of organization, like white fibrous tissue or bone, and hence, 

 although breaches in the higher structures like muscle, 

 nerve, gland, skin, are filled up, it is usually only by the 

 drawing together of the remaining healthy parts by these 

 new formations without the restoration of any of the origi- 

 nal tissue which has been destroyed. The cicatrix (scar), 

 alone is made up of new material. 



Lymph developing in this way may undergo any degen- 

 eration to which normal tissues are subject. Thus it may 

 undergo black pigmentary {melanotic) degeneration, it may 



