Injlammation and Fever. 



their functions impaired or lost ; the inflamed skin in the 

 frog has its pigment-cells unchanged while all the body be- 

 side has changed color, the inflamed retina no longer sees, 

 the inflamed nose no longer smells, the inflamed mamma no 

 longer yields milk, the inflamed finger has no more the 

 proper sense of touch, and the inflamed cells that control 

 nutrition no longer build up the tissues amid which they 

 lie, but tend rather to a simple multiplication of their own 

 cell forms, as do the cells of the early growing embryo. 

 7th. In an extensive inflammation the large arteries pro- 

 ceeding to the diseased part have their coats abnormally 

 rigid, giving a harder beat to the pulse and determining a 

 more abundant flow of blood than in the corresponding ves- 

 sels of the healthy part. This doubtless results from the 

 disorder of the vaso-motor (sympatlietic) nerves, and this 

 disorder is involved in the causation of the derangement of 

 the capillary circulation as well, since the cutting across of a 

 branch of these nerves going to a part promptly induces in- 

 flammatory changes in such part. This tendency to the 

 production of inflammation through nervous influence is 

 further shown in the extension to the otlier of a violent in- 

 flammation of one eye caused by a mechanical injin-y. Yet 

 the essential changes may be induced in the tissues by irri- 

 tants, though the nerves proceeding to the part have been 

 cut or the blood-vessels tied. 



It is worthy of notice that in extensive inflammations 

 in otherwise healthy systems the circulating blood acquires 

 a great increase of fibrinogen (often doubled), and the blood- 

 globules become abnormally adhesive, so that before the 

 drawn blood has time to coagulate the globules adhere to- 

 gether in masses and precipitate toward the bottom, leaving 

 the upper layers of the clot of a dull yellow hue (buffy coat). 

 This is shown in the blood of the healthy soliped, but in 

 other animals it implies inflammation, apart from the condi- 

 tions of plethora, anaemia, pregnancy, or over-driving. In 



