(JontoLgious and Epizootic Diseases. 59 



THI. IMMTOTITr BY INOCULATION IN AIT UNIMPORTANT 



OEGAN. 



This has been especially resorted to in lung plague after 

 the mode of Willems, of Hasselt, Belgium. The liquid 

 exudate from the diseased lung, recently attacked and still 

 gorged with an uncoaguiated liquid, is inserted into the tail 

 near the tip. In fifteen days, on an average, it becomes in- 

 flamed, swollen, and it may even slough, but after recovery 

 the system is fortified against the disease. Inoculated else- 

 where in the body where there is an abundant connective 

 tissue beneath the skin it is usually fatal, but in the tail, with 

 its dense texture and deficiency of lymphatic tissue, it rarely 

 extends to dangerous dimensions. 



IX. IMMUNITY BY INOCULATON IN THE VEINS. 



In 1879 Burdon-Sanderson inoculated cattle with the lung- 

 plague virus by injecting the same into the veins, without 

 any contact with the adjacent tissues. The inoculated cattle 

 showed no special disorder, but when afterward inoculated 

 in the tissues with fresh virus they proved to be entirely in- 

 susceptible of it. Later, Gal tier adopted the same measure 

 with the saliva of canine madness, injecting it into the veins 

 of rabbits and sheep with no direct evil result, and the sub- 

 jects afterward resisted the infection by inoculation in the 

 tissues. Lussano long before, and Pasteur later, made in- 

 travenous injections in dogs, but with the result of inducing 

 rabies. The method, then, must have a very limited appli- 

 cation, being restricted to such disease-germs as do not sur- 

 vive in the blood. It is utterly inapplicable to diseases in 

 which the blood is habitually infecting, such as syphilis, 

 glanders, tuberculosis, rabies in dogs, anthrax, etc. 



