The Molds 



43 



form of reproduction also takes place through the production of 

 ascospores. Many species are known, only a few of which are 

 pathogenic. 



Aspergillus malignum has been found by von Lindt in the auditory 

 meatus of man. 



Aspergillus nidulans occasionally infects cattle. It is pathogenic 

 for laboratory animals, usually causing death in sixty hours. The 

 kidneys are found enlarged to twice their normal size, and show small 

 whitish dots and stripes of cell infiltration containing the fungi. 



Fip. 13. — Aspergillus glaucus: A, A portion of the mycelium m, with a con- 

 idiaphore c, and a young perithrecium F, magnified 190 diameters; B and B', 

 conidiaphore with conidia; B, individual sterigma greatly magnified; C, early 

 stage of the development of the fructif5nng organ; T>, young perithrecium in 

 longitudinal section; w, the future wall of the contents; as, the screw, magnified 

 250 diameters; E, an ascus with spores from a perithrecium, magnified 600 

 diameters. (duBary.) 



The heart muscle, diaphragm, and spleen may also be involved. 

 The liver usually escapes. It takes a large number of spores to 

 infect. 



Aspergillus fumigatus. — This is a widespread and not infrequently 

 pathogenic form. Its most common lesion is a pneumomycosis, in 

 which the lung is riddled with small inflammatory necrotic and 

 cavernous areas containing the molds. The same condition has 

 occasionally been observed in human beings, Sticker having collected 

 39 cases.* 



Leber and others have observed keratitis following corneal infec- 

 tion by this organism. 



Aspergillus flavus is also pathogenic. 



* Nothnagel's Spezielle Path. u. Therap., xiv, 1900. 



