474 



Malaria 



fection of the knowledge of the parasite was reached in 191 1, when 

 C. C. Bass* devised a method of cultivating the parasite in its 

 asexual stage, in vitro. 



Thus from its time-honored place as the typical miasmatic disease, 

 full of mystery and obscurity, malarial fever suddenly had a flood 

 of light thrown upon it by which every peculiarity was fully 

 illuminated. 



In summarizing the knowledge thus set forth we find the following 

 facts: 



1880 — Discovery of the Plasmodium malariae by Laveran. 



1890 — Discovery of its human developmental cycle by Golgi. 



189s — Discovery of the mosquito cycle and mode of transmission 

 by Ross. 



1898 — Discovery of the sexual fertilization of the parasite by 

 MacCallum. 



191 1 — Discovery of the method of cultivating the parasites in 

 vitro by C. C. Bass. 



The interest aroused by Laveran's original discovery gave a great 

 impetus to the study of hematology with special reference to para- 

 sites, and it soon became evident that the plasmodium was but one 

 of a group of similar parasites. Of these we have now become ac- 



' Journal of the American Medical Association," 1911, XLVii, 1534. 



