So8 



Sleeping Sickness 



micro-organisms and African lethargy, and much interest was being 

 taken in a coccus— the hypnococcus — that was being studied by 

 Castellani in Uganda. As Castellani was prosecuting the investi- 

 gation of this organism, he chanced to examine the cerebro-spinal 

 fluid of several negroes in Uganda who were sufifering from sleeping 

 sickness, and in it found trypanosomes. Even then, though Cas- 

 tellani* realized that these organisms were connected with sleeping 

 sickness, he did not identify them in his mind with the Trypano- 



Fig. 207. — Various species of trypanosomes : i, Trypanosoma lewisi oi the ia.t; 

 2, Trypanosoma lewisi, multiplication rosette; 3, Trypanosoma lewisi, small form 

 resulting from the disintegratoin of arosette; 4, Trypanosoma brticei of nagana; 

 S, Trypanosoma equinum of caderas; 6, Trypanosoma gambienseoi sXee.'paigSLdL- 

 ness; 7, Trypanosoma gambiense, undergoing division; 8, Trypanosoma theileri, 

 a harmless trypanosome of cattle; 9, Trypanosoma transvaliense, a variation of 

 T. theileri; 10, Trypanosoma avium, a bird trjfpanosome; 11, Trypanosoma 

 damonice of a tortoise; 12, Trypanosoma solece of the flat fish; 13, Trypanosoma 

 granulosum of the eel; 14, Trypanosoma rajrn of the skate; 15, Trypanosoma rola- 

 torium of frogs; 16, Cryptobiaborreli of the red-eye (a fish). (From Laveran and 

 Mesnil.) 



* Ibid., May 23, 1903; June 20, 1903. 



