526 



Kala-Azar 



Leishman's, or Jenner's stains) and examined under a high magnifi- 

 cation, it is found that the protoplasm takes a pinkish color and 

 contains two well-defined bright red bodies. The larger of these 

 is ovoid and lies excentrically, its long diameter corresponding to 





^ ig; !^ 



..^s 



>**. 



4« © •* .v^F 



c? 





Fig. 216. — ^Evolution of the parasite of kala-azar: i to 5. Parasites of kala- 

 azar. i Isolated parasites of different forms in the spleen and liver; 2, division 

 forms from liver and bone-marrow; 3, mononuclear spleen cells containing the 

 parasites; 4, group of parasites; 5, phagocytosis of a parasite by a polynuclear 

 leukocyte. 6 to 15. Parasites from cultures. 6, First changes in the parasites. 

 The protoplasm has increased in bulk and the nucleus has become larger; 7, 

 further increase in size; vacuolization of the protoplasm; 8, division of the en- 

 larged parasite; 9, evolution of the flagella; 10, small pyriform parasite showing 

 flagelliun; 11, further development and dixasion of the parasite; 12, flagellated 

 trjTJanosoma-like form; 13, 14, flagellated forms dividing by a splitting off of a 

 portion of the protoplasm; 15, narrow flagellated parasites which have arisen by 

 the type of division shown in 13 and 14. (From Mense's "Handbuch," after 

 Leishman.) 



the long diameter of the organism. This is regarded as the nucleus. 

 The second body is smaller and of bacillary shape, and usually lies 

 with its: long diameter transverse to the nucleus. This is looked upon 

 as a bl^pliajfopjkBt. . It stains more intensely than the nucleus. 



