Specific Therapy 60 1 



In 1903 Wright* pubUshed new statistics on the subject, and 

 between 1903 and 1908 numerous references to the subject appear 

 in the "British Medical Journal," in the "Lancet," and in the 

 "Journal of the Royal Army Medical Corps," all favorable in their 

 general attitude. 



During the Mexican Revolution of 1911, the United States Govern- 

 ment began, on March 10, 191 1, the mobilization of regiments of the 

 United States Army on the Mexican frontier near San Antonio, 

 Texas. In order to prevent repetition of the sad experiences of the 

 Spanish-American War, in which the troops suffered terribly from 

 typhoid fever, the Secretary of War determined that the entire 

 command should be immunized against the disease. Many of the 

 soldiers arriving on the ground had already been immunized, the re- 

 mainder were at once given the necessary injection upon arrival. 

 The mean strength of the command at San Antonio was 12,000 up 

 to June 30, 1911, a period approximating four months. During all 

 that time there were only 2 cases of typhoid fever in the encamp- 

 ment, I in an uninoculated civilian teamster and i in an inoculated 

 soldier. Both cases recovered. The soldier suffered from so mild 

 an attack that it would not have been diagnosed had not a blood- 

 culture been made. During the four months from March loth 

 to June 30th the typhoid fever was prevalent among the civilians 

 of San Antonio, there being 40 cases with 19 deaths. f 



The prophylactic used was prepared from a specially selected 

 strain of Bacillus typhosus grown on agar-agar in KoUe flasks for 

 twenty-four hours. The growth was washed off with normal salt 

 solution, killed by heating at 55° to s6°C. in a water-bath, standard- 

 ized by coimting the bacteria according to the method of Wright, 

 and after being diluted with salt solution, 0.25 per cent, of trikresol 

 was added. One cubic centimeter of the finished prophylactic con- 

 tained 1,000,000,000 bacilli. The first dose injected contained 

 500,000,000 bacilli, the second and third, given after ten and twenty 

 days, contained 1,000,000,000 each. The injections caused little 

 inconvenience either locally or constitutionally. Only i case had 

 fever, chills, and sweats, and this was the only case requiring 

 treatment in the hospital. It subsequently developed that this 

 soldier was suffering from early tuberculosis, which may explain the 

 untoward symptoms from which he suffered. 



Specific Therapy. — Animals can be immunized to this bacillus, and 

 then, according to Chantemesse and Widal, develop antitoxic blood 

 capable of protecting other animals. SternJ found in the blood of 

 human convalescents a substance thought to have a protective effect 

 .upon infected guinea-pigs. His observation is in accordance with a 



* "Brit. Med. Jour.," Oct. 10, 1903. 



t "Report of the Surgeon-General of the United States Army to the Secretary 

 of War," 1911, Washington, D. C. 

 I "Zeitschrift fur Hygiene," 1894, xvi, p. 458. 



