Glanders. 243 



accummulate in the perivascular sheaths and lymph plexuses, the 

 walls of the lymphatic trunks running out of these swellings 

 become swollen and indurated and at intervals, mostly on the 

 seat of the valves there is the proliferation of small round cells 

 to form farcy buds. In chronic cases the fibroid thickening in- 

 volves the skin, subcutaneous connective tissue and walls of the 

 lymph vessels binding the whole into one dense resistant mass, 

 more or less studded with corded lymphatics, firm nodules, and 

 ulcerous sores. 



The lymphatic glands in the line of circulation from the infected 

 centres are constantly involved. Hypertrophy, congestion, 

 serous infiltration, and rapid cell proliferation are present and a 

 section will usually show caseated or caseopurulent centres con- 

 fined by the outer dense fibrous envelope. Exceptionally, these 

 necrosed contents will escape through an ulcerous opening, form- 

 ing a deep cavity which is slow and difiicult to heal. In the vi- 

 cinity of these glands and in the loose intermuscular connective 

 tissue abscesses of the size of an egg or an orange or larger are 

 sometimes met with. 



Nodules and ulcers are found on the pharyngeal and intestinal 

 mucosa, similar to those of the larynx. 



The spleen, and less frequently the liver, may be the seat of 

 caseating nodules exactly comparable to those of the lungs. 

 Glanders of the kidney is rare. 



Nodules have been seen on the ventricular endocardium and 

 one case of nodules of the choroid plexus (Boschetti). 



In stallions, glanderous, caseating foci in the testicle and dropsy 

 of the scrotum are common, while mares may have similar forma- 

 tions in the mammary glands or ulcers of the vaginal or uterine 

 mucosa. 



Infiltrations of the joints and other synovial cavities are not 

 uncommon and glanderous infiltration of the bones with caries is 

 also found. In chronic cases, fragility of the bone is marked, 

 and the blood contains an excess of leucocytes. These may be 

 traced to disease of the bone marrow, as well as of the spleen and 

 lymphatic system. 



GLANDERS IN SWINE. 



The healthy, vigorous pig is practically immune. Experi- 

 mental inoculations have uniformly failed to produce the disease. 



