Glanders. 245 



seat of inoculation are slight, but there persist engorgements of 

 the adjacent lymph glands, swelling (cording) of the lymph ves- 

 sels adjacent, and nodules and abscesses, (cutaneous, subcutane- 

 ous, intermuscular, intravisceral), arthritis, emaciation, dyspnoea 

 and death in two to four months. In some cases with a very 

 small dose of the poison, there is no local swelling, and no gen- 

 eralization nor subsequent manifestation of the disease. 



In the rabbit the lesions are less certain and often less marked. 

 There is sometimes no swelling in the seat of inoculation, in the 

 neighboring lymph glands, nor elsewhere, and the rodent might 

 have been supposed to have escaped, only that successful inocu- 

 lation of the ass may be made from the tissues inoculated (Galtier) . 

 In such a case a certain immunity of the rabbit must be inferred. 

 In less resistant rabbits, or with a larger dose, an ulcerous swell- 

 ing forms in the seat of inoculation, the adjacent lymph glands 

 become engorged or even purulent, corded lymphatics intervene, 

 and nodules and caseous degenerations appear in the lungs, nose, 

 spleen, liver, and other organs. 



The hedgehog, ground squirrel, the field mouse, house mouse, 

 mole have been successfully inoculated. 



The/ri?^ immersed in water at 30° C, forms a good culture 

 ground for the bacillus which may be found in its blood, in pure 

 cultures, from the second to the fifty-fifth day. These cause no 

 local lesion, nor obvious, constitutional disorder. It seems possi- 

 ble that, in summer, the infection may be propagated by frogs in 

 the drinking water. 



GLANDERS IN CARNIVORA. 



All carnivora are liable to contract glanders by eating the flesh 

 of glandered horses, asses and mules, and this has been noted 

 especially in menageries. Lions, tigers, bears and wolves, have 

 shown the ulcerous lesions in the nose, and the nodules in the 

 lungs, spleen, liver, kidneys and elsewhere. The carcass of the 

 diseased horse is, however, often devoured without evil result, 

 and even when the carnivora become affected the disease is not 

 always fatal. 



In the dog, experimental glanders has been closely studied by 

 many observers. Casual glanders has been contracted by living 

 with the glandered horse ; by licking his nasal or other discharges, 



